Research Area: Immunity and Cancer
Background: During is his PhD, at The Gulbenkian Institute (Oeiras, Portugal), Dinis studied anti-inflammatory cytokines in the immune system. For his Postdoctoral work Dinis joined Harvard Medical School (Boston, USA), where he developed clinically relevant mouse models of cancer, including for Diffuse Large B-cell Lymphoma, Burkitt’s Lymphoma, and identified in vivo subpopulations of Germinal Centre B-cells with high expression of the proto-oncogene MYC, that may represent precursors of these diseases.
Current Research: Dinis’ laboratory at The Francis Crick Institute (London, UK) uses an integrated approach to immunology and cancer and aims to elucidate mechanisms by which healthy cells become cancerous, and of the interplay between cancer cells and their microenvironment. Dinis’ laboratory performs research on immune cell development and processes; including autoimmunity, response to infection; and uses that knowledge to understand development of B-cell lymphomas. Example of ongoing work are the generation of mouse model systems of human relapse/refractory Diffuse Large B-cell Lymphoma, and to understand mechanistically how the proto-oncogene MYC relates to therapy resistance.